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KMID : 0371319840260040419
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Journal of the Korean Surgical Society
1984 Volume.26 No. 4 p.419 ~ p.425
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Duodenal Osmoregulation after Total Parenteral Nutrition in Neonatal Piglets
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Shin Taik-Soo
Dennis W. Shermeta
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Abstract
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The physiologic effects of intestinal rest on the efficiency of gastroduodenal osmoregulation of hypertonic and hypotonic carbohydrate meals was studied in neonatal piglets, 3-5 days old. Sixteen piglets underwent laparotomy, gastrostomy and end-jejunostomy just distal to tue ligament of Treitz. Sixteen littermates had insertion of a central venous catheter and received 2 weeks of TPN before laparotomy, gastrostomy and end-jejunostomy. Experiments were performed 2 days after laparotomy in all groups. Each piglet received intragastric infusions of 2 test meals (25 cc/kg), half the pigs receiving glucose (494±11; 147±3), and half mannitol (493±11; 150±4) mOsm/L±SD. Gastric samples and jejunal effluent were collected every 30 minutes for 2 hours. TPN did not influence duodenal osmoregulation. Significant changes in osmolality cccurred during duodenal transit after all meals and these changes were similar for all groups. However, jejunal osmolality did not approach basal levels until late in the observation period. These results domonstrate significant but incomplete intraduodenal osmoregulation of carbohydrate meals in neonatal piglets which is unaffected by 2 weeks of intestinal rest.
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